Acid-sensing ion channels modulate bladder nociception-Reference-Cited by-同舟云学术

Acid-sensing ion channels modulate bladder nociception

Published:2021-11-01 Issue:5 Volume:321 Page:F587-F599
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Montalbetti Nicolas¹^ORCID,Carattino Marcelo D.¹²^ORCID

Affiliation:

1. Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

2. Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania

Abstract

Our study indicates that protons and their cognate acid-sensing ion channel receptors are part of a mechanism that operates at bladder afferent terminals to control their function and that the loss of this regulatory mechanism results in hyperactivation of nociceptive pathways and the development of pain in the setting of chemical-induced cystitis.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Urology Care Foundation

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00302.2021

Reference80 articles.

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4. The Urothelium: Life in a Liquid Environment

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