Bladder infection with uropathogenic Escherichia coli increases the excitability of afferent neurons-Reference-Cited by-同舟云学术

Bladder infection with uropathogenic Escherichia coli increases the excitability of afferent neurons

Published:2022-01-01 Issue:1 Volume:322 Page:F1-F13
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Montalbetti Nicolas¹^ORCID,Dalghi Marianela G.¹,Bastacky Sheldon I.²,Clayton Dennis R.¹,Ruiz Wily G.¹,Apodaca Gerard¹³^ORCID,Carattino Marcelo D.¹³^ORCID

Affiliation:

1. Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

2. Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania

3. Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania

Abstract

Urinary tract infection (UTI) produced by uropathogenic Escherichia coli (UPEC) promotes sensitization of bladder afferent sensory neurons with tetrodotoxin-resistant and tetrodotoxin-sensitive action potentials. Lipopolysaccharide and other virulence factors produced by UPEC contribute to the sensitization of bladder afferents in UTI. In conclusion, sensitized afferents contribute to the voiding symptoms and pelvic pain present in mice bladder inoculated with UPEC.

Funder

Pittsburgh Center for Kidney Research

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Urology Care Foundation

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00167.2021

Reference107 articles.

1. The immune response to infection in the bladder