Dynamics of the cerebral autoregulatory response to paced hyperventilation assessed using subcomponent and time-varying analyses-Reference-Cited by-同舟云学术

Dynamics of the cerebral autoregulatory response to paced hyperventilation assessed using subcomponent and time-varying analyses

Published:2022-08-01 Issue:2 Volume:133 Page:311-319
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Clough Rebecca H.¹,Minhas Jatinder S.¹²^ORCID,Haunton Victoria J.¹²,Hanby Martha F.¹,Robinson Thompson G.¹²,Panerai Ronney B.¹²^ORCID

Affiliation:

1. Department of Cardiovascular Sciences, Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, University of Leicester, Leicester, United Kingdom

2. NIHR Leicester Biomedical Research Centre, British Heart Foundation Cardiovascular Research Centre, Glenfield Hospital, Leicester, United Kingdom

Abstract

The dynamic response of critical closing pressure (CrCP) and resistance-area product (RAP) of the cerebral circulation to a step change in mean arterial pressure can shed light on the nonstationary changes induced by paced hyperventilation and the effects of hypocapnia on the autoregulation of cerebral blood flow. Contrary to hypercapnia, where the response is dominated by CrCP, hypocapnia shows an initial depression of cerebral autoregulation, followed by improvements controlled by changes in RAP.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00100.2022

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