The effect of CO<sub>2</sub> on the age dependence of neurovascular coupling-Reference-Cited by-同舟云学术

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The effect of CO₂ on the age dependence of neurovascular coupling

Published:2024-08-01 Issue:2 Volume:137 Page:445-459
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Davies Aaron¹^ORCID,Gurung Dewarkar¹,Ladthavorlaphatt Kannaphob¹^ORCID,Mankoo Alex¹,Panerai Ronney B.¹²^ORCID,Robinson Thompson G.¹²,Minhas Jatinder S.¹²^ORCID,Beishon Lucy C.¹²^ORCID

Affiliation:

1. Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

2. NIHR Leicester Biomedical Research Centre, Glenfield Research Centre, British Heart Foundation Cardiovascular Centre, Leicester, United Kingdom

Abstract

This study describes the effects of age on neurovascular coupling under altered CO2 conditions. We demonstrated that both hypercapnia and hypocapnia suppress neurovascular coupling (NVC) responses. Furthermore, that middle age exhibits an NVC response comparable with younger adults under hypercapnia, and older adults under hypocapnia.

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00695.2023

Reference92 articles.

1. Ageing as a risk factor for neurodegenerative disease

2. Mechanisms of Vascular Aging

3. McDonald's Blood Flow in Arteries

4. The assessment of neurovascular coupling with the Addenbrooke’s Cognitive Examination: a functional transcranial Doppler ultrasonographic study

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