SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload-Reference-Cited by-同舟云学术

SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload

Published:2021-02-01 Issue:2 Volume:320 Page:H604-H612
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Riley Hannah J.¹,Kelly Ryan R.²³,Van Laer An O.¹,Neff Lily S.¹,Dasgupta Shaoni¹,Baicu Catalin F.¹,McDonald Lindsay T.²³,LaRue Amanda C.²³,Zile Michael R.¹³,Bradshaw Amy D.¹³

Affiliation:

1. Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina

2. Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina

3. Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina

Abstract

Myocardial fibrosis and the resultant increases in LV and myocardial stiffness represent pivotal consequences of chronic pressure overload (PO). In this study, a murine model of cardiac fibrosis induced by PO was used to demonstrate a critical function of SPARC in bone marrow-derived cells that drives cardiac fibrosis and increases in cardiac macrophages.

Funder

U.S. Department of Veterans Affairs

Office of Extramural Research, National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00552.2020

Reference22 articles.

1. Left Ventricular Structural Remodeling in Health and Disease

2. Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction