Role of macrophages in regression of myocardial fibrosis following alleviation of left ventricular pressure overload-Reference-Cited by-同舟云学术

Role of macrophages in regression of myocardial fibrosis following alleviation of left ventricular pressure overload

Published:2024-05-01 Issue:5 Volume:326 Page:H1204-H1218
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Neff Lily S.¹,Biggs Rachel M.¹,Zhang Yuhua¹,Van Laer An O.¹,Baicu Catalin F.¹^ORCID,Subramanian Suganya²^ORCID,Berto Stefano²,DeLeon-Pennell Kristine¹³^ORCID,Zile Michael R.¹³,Bradshaw Amy D.¹³^ORCID

Affiliation:

1. Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States

2. Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, United States

3. The Ralph H. Johnson Department of Veteran’s Affairs Medical Center, Charleston, South Carolina, United States

Abstract

Our novel findings highlight the dynamic changes in myocardial macrophage populations that occur in response to PO and after alleviation of PO. Our data demonstrated, for the first time, a potential benefit of macrophages in contributing to collagen degradation and the partial regression of interstitial fibrosis following normalization of hemodynamic load.

Funder

DOD | USAF | AMC | Air Force Research Laboratory

HHS | NIH | National Institute of General Medical Sciences

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00240.2023

Reference28 articles.

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3. Time course of regression of left ventricular hypertrophy after aortic valve replacement.

4. Mechanisms that limit regression of myocardial fibrosis following removal of left ventricular pressure overload

5. SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload

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