Female rats are less prone to clinical heart failure than male rats in a juvenile rat model of right ventricular pressure load-Reference-Cited by-同舟云学术

Female rats are less prone to clinical heart failure than male rats in a juvenile rat model of right ventricular pressure load

Published:2022-06-01 Issue:6 Volume:322 Page:H994-H1002
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Bossers Guido P. L.¹^ORCID,Hagdorn Quint A. J.¹^ORCID,Koop Anne-Marie C.¹,van der Feen Diederik E.¹,Bartelds B.¹²^ORCID,van Leusden Tom¹,De Boer Rudolf A.³,Silljé Herman H. W.³,Berger Rolf M. F.¹

Affiliation:

1. Center for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

2. Division of Pediatric Cardiology, Department of Pediatrics, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, The Netherlands

3. Department of Cardiology, Laboratory for Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Abstract

In this study, we describe sex differences in our unique weanling rat model of increased RV pressure load by pulmonary artery banding. We are the first to assess temporal sex-related differences in RV adaptation during pubertal development. Female rats show superior RV function and less diastolic dysfunction and fibrosis compared with male rats. These differences are already present before puberty, indicating that the differences in RV adaptation are not only determined by sex hormones.

Funder

Sebald Fund

Stichting Hartekind

Royal Netherlands Academy of Sciences

Hartstichting

Dutch Federation of University Medical Centres

ZonMw

The Netherlands CardioVascular Research Initiative

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology