Antibacterial activity of metallic-core gold and silver nanoparticles against some animal pathogens

Author:

Aksoy Adil1,Alazragi Reem2,Alabdali Aya Y.M.3,Aljazzar Raed4,El Sadi Salah5,Alostaz Mohammed6,El Hindi Mahmoud7

Affiliation:

1. 1 Department of Veterinary Science , Eskil Vocational School, Aksaray University , Aksaray , Turkey

2. 2 Department of Biochemistry, Faculty of Science , University of Jeddah , Jeddah , Kingdom of Saudi Arabia

3. 3 The University of Mashreq and UCSI University , Faculty of Pharmacy , Baghdad , Iraq

4. 4 Industrial Department , Ministry of National Economy , Gaza , Palestine

5. 5 Precious Metals Laboratory Department , Ministry of National Economy , Gaza , Palestine

6. 6 Consumer Protection Department, Ministry of National Economy , Gaza , Palestine

7. 7 Department of Biotechnology, Faculty of Science , Islamic University of Gaza , Gaza , Palestine

Abstract

Abstract The current work aimed to find substitutes for antibiotics because of the side effects of antibacterial agents and the expansion of bacterial resistance to these agents. The scope of this study was to evaluate the antibacterial activity of gold and silver nanoparticles (AuNPs and AgNPs) against selected animal pathogens (Staphylococcus aureus, Klebsiella pneumonia, Streptococcus pneumoniae, Escherichia coli, Bacillus abortus and Mycobacterium bovis). The synthesized nanoparticles were distinguished by scanning electron microscopy (SEM) analysis and tested for antibacterial activity with the broth microdilution method, well diffusion assay, and minimum bactericidal concentration procedure. Results showed that both AuNPs and AgNPs displayed good antibacterial activity against all tested bacteria. The strongest antibacterial action of AgNPS (18 mm) was against E. coli. AuNPs displayed good antibacterial activity against S. aureus and B. bovis with a suppression area of 14 mm. Therefore, it is suggested that AgNPs and AuNPs could be effectively used against animal pathogens and may contribute to reducing antibiotic resistance. However, there is a need for further research on the in vivo toxicity and mechanisms of action of AuNPs and AgNPs.

Publisher

Walter de Gruyter GmbH

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