Author:
Shipovalov A. V.,Vanin A. F.,Pyankov O. V.,Bagryanskaya E. G.,Mikoyan V. D.,Tkachev N. A.,Asanbaeva N. A.,Popkova V. Ya.
Abstract
Abstract
The antiviral action of binuclear dinitrosyl iron complexes with glutathione along with diethyldithiocarbamate against the SARS-CoV-2 virus has been demonstrated on a Syrian hamster model after aerosol exposure of SARS-CoV-2-infected animals to the solutions of said compounds. EPR assays in analogous experiments on intact hamsters have demonstrated that the iron complexes and diethyldithiocarbamate are predominantly localized in lung tissues. These results have been compared with similar measurements on intact mice, which have shown the equal localization of these agents in both the lungs and liver. We assume that the release of the nitrosonium cations from the binuclear dinitrosyl iron complexes with glutathione occurs during their contact with diethyldithiocarbamate in the animal body. These cations caused S-nitrosation of host and viral cell proteases, leading to suppression of SARS-CoV-2 infection.
Reference39 articles.
1. N. O. Bykova, N. V. Gorbunov, A. P.Volgarev, et al., Byull. Eksp. Biol. Med. 112, 617 (1991).
2. G. Karupian and N. Harris, J. Exp. Med. 181, 2171 (1995).
3. C. J. Lowenstein, S. L. Hill, A. Lafond-Walker, et al., Clin. Invest. 92, 1837 (1996).
4. E. Peterhans, Biol. Trace Element Res. 56, 107 (1997).
5. C. S. Reiss and T. Kamatsu, J. Virol. 72, 4547 (1998).
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献