Affiliation:
1. N.N.Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences
Abstract
It has been shown that the inhalation of gaseous NO (exogenous nitric oxide) leads to the formation of nitrosonium cations (NO+) in the circulating blood of humans and animals during the oxidation of NO, which can have a detrimental effect on pathogenic viruses and bacteria. When thiols enter the blood simultaneously with NO inhalation, they form S-nitrosothiols with NO+ and cause hypotensive effect in animals. The biological effect of endogenous NO, which is produced in cells and tissues with the participation of NO synthases in animals and humans, is mediated by the dinitrosyl iron complexes (DNIC) formed with thiol-containing ligands. As NO and NO+ donors, these complexes have a variety of regulatory and cytotoxic effects on the animal and human body. In particular, the NO+ released by DNIC was shown to suppress SARS-CoV-2 infection in Syrian hamsters.
Publisher
Scientific and Practical Reviewed Journal Pulmonology
Reference53 articles.
1. Vanin A.F. [Dinitrosyl iron complexes with thiol-containing ligands: Physical chemistry, biology, medicine]. Moscow, Izhevsk: Institut komp'yuternykh issledovaniy; 2015 (in Russian).
2. Vanin A.F. Dinitrosyl iron complexes as a “working form” of nitric oxide in living organisms. Cambridge: Cambridge Scholar Publishing; 2019.
3. Vanin A.F. [Positive (regulatory) and negative (cytotoxic) action of dinitrosyl iron complexes on living organisms]. Biokhimiya. 2022; 87 (11): 1739–1760. DOI: 10.31857/S0320972522110173 (in Russian).
4. Chazov E.I., Rodnenkov O.V., Zorin A.V. et al. Hypotensive effect of Oxacom® containing a dinitrosyl iron complex with glutathione: animal studies and clinical trials on healthy volunteers. Nitric Oxide. 2012; 26 (3): 147–157. DOI: 10.1016/j.niox.2012.01.008.
5. Galagan M.E., Oranovskaya E.V., Mordvintsev P.I. et al. [Hypotensive effect of dinitrosyl iron complexes in experiments on waking animals]. Byulleten' Vsesoyuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR. 1988; 11 (2): 73–79 (in Russian).