Immortalization of Human Keratinocytes Using the Catalytic Subunit of Telomerase-Reference-Cited by-同舟云学术

Immortalization of Human Keratinocytes Using the Catalytic Subunit of Telomerase

Published:2021-03-10 Issue:1 Volume:496 Page:5-9
ISSN:1607-6729
Container-title:Doklady Biochemistry and Biophysics
language:en
Short-container-title:Dokl Biochem Biophys

Author:

Beilin A. K.,Gurskaya N. G.,Evtushenko N. A.,Alpeeva E. V.,Kosykh A. V.,Terskikh V. V.,Vasiliev A. V.,Vorotelyak E. A.

Abstract

Abstract A new stable line of human keratinocytes was obtained. The cells have altered morphology, both abnormal chromosomal composition and expression of keratinocyte markers, do not show contact inhibition, could be cultured in various media and have limited stratification ability in vitro. Upon transplantation into nude mice the cells have tumorigenic properties.

Publisher

Pleiades Publishing Ltd

Subject

General Chemistry,Biochemistry,General Medicine,Biophysics

Link

http://link.springer.com/content/pdf/10.1134/S1607672921010014.pdf

Reference10 articles.

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