Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/23962.pdf
Reference30 articles.
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4. Allsopp, R. C.et al. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl Acad. Sci. USA 89, 10114–10118 (1992).
5. Bodnar, A. G.et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349–352 (1998).
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