Direct and Regioselective C(sp3)–H Bond Fluorination of 2-Alkylazaarenes with Selectfluor-Reference-Cited by-同舟云学术

Direct and Regioselective C(sp3)–H Bond Fluorination of 2-Alkylazaarenes with Selectfluor

Published:2020-10-07 Issue:06 Volume:53 Page:1157-1162
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Chausset-Boissarie Laëtitia¹^ORCID,Le Guen Clothilde¹,Mazzah Ahmed¹,Penhoat Maël¹,Melnyk Patricia²,Rolando Christian¹

Affiliation:

1. USR CNRS 3290, MSAP, Miniaturisation pour la Synthèse, l’Analyse et la Protéomique, Université de Lille

2. Inserm, CHU Lille, U1172-Lille Neuroscience & Cognition, Université de Lille

Abstract

AbstractHerein, a regioselective and direct monofluorination strategy of pyridylic and quinolinic C(sp3)–H bonds was developed under transition-metal-free conditions with Selectfluor. The reaction was performed under smooth conditions and afforded fluorinated azaheterocycles including 2-methylpyridines and -quinolines in moderate to good yields.

Funder

Centre National de la Recherche Scientifique

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1706482.pdf

Reference10 articles.

1. Novel Derivatives of 2-Pyridinemethylamine as Selective, Potent, and Orally Active Agonists at 5-HT1A Receptors

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