Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).-Reference-Cited by-同舟云学术

Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).

Published:2009-07-24 Issue:16 Volume:52 Page:5188-5196
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Verhoest Patrick R.¹,Chapin Douglas S.¹,Corman Michael¹,Fonseca Kari¹,Harms John F.¹,Hou Xinjun¹,Marr Eric S.¹,Menniti Frank S.¹,Nelson Frederick¹,O’Connor Rebecca¹,Pandit Jayvardhan¹,Proulx-LaFrance Caroline¹,Schmidt Anne W.¹,Schmidt Christopher J.¹,Suiciak Judith A.¹,Liras Spiros¹

Affiliation:

1. Neuroscience, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900521k

Reference23 articles.

1. Phosphodiesterase 5 Inhibitors for Erectile Dysfunction

2. The Next Generation of Phosphodiesterase Inhibitors: Structural Clues to Ligand and Substrate Selectivity of Phosphodiesterases

3. Immunohistochemical localization of PDE10A in the rat brain