Recent Advancements in the Synthesis of α-fluoroalkylated Azine-derived
Heterocycles through Direct Fluorination
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Published:2023-11-02
Issue:
Volume:21
Page:
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ISSN:1570-1794
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Container-title:Current Organic Synthesis
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language:en
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Short-container-title:COS
Author:
Shavrina Oksana1ORCID,
Rassukana Yuliya1,
Onysko Petro1ORCID
Affiliation:
1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Akademika Kukharya str., Kyiv 02660, Ukraine
Abstract
Abstract::
The review highlights recent advancements in the synthesis of α-fluoro and α,α-
difluoroalkylated azines, focusing on two main approaches. The first approach involves nucleophilic
deoxofluorination, wherein α-hydroxy- or α-oxoalkylated azines are treated with diethylaminosulfur
trifluoride or other S-F reagents to introduce fluorine atoms. The second approach
employs direct electrophilic benzylic fluorination, whereby alkylazines undergo fluorination
using N-F reagents. Both methods provide flexibility in designing and synthesizing
fluoroalkylated heterocycles.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry