Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia

Author:

Ananth Cande12,Jablonski Kathleen3,Myatt Leslie4,Roberts James5,Tita Alan6,Leveno Kenneth7,Reddy Uma,Varner Michael8,Thorp John9,Mercer Brian10,Peaceman Alan11,Ramin Susan12,Carpenter Marshall13,Samuels Philip14,Sciscione Anthony15,Tolosa Jorge16,Saade George17,Sorokin Yoram18,

Affiliation:

1. Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Joseph L. Mailman School of Public Health, Columbia University, New York, New York

2. Department of Health Policy and Management, Joseph L. Mailman School of Public Health, Columbia University, New York, New York

3. Department of Obstetrics and Gynecology, Biostatistics Center, The George Washington University, Washington, District of Columbia

4. Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio

5. Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania

6. Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama

7. Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas

8. Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah

9. Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

10. Department of Obstetrics and Gynecology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio

11. Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois

12. Department of Obstetrics and Gynecology, Children's Memorial Hermann Hospital, The University of Texas Health Science Center at Houston, Houston, Texas

13. Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island

14. Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio

15. Department of Obstetrics and Gynecology, Drexel University, Philadelphia, Pennsylvania

16. Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon

17. Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas

18. Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan

Abstract

Objective To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s). Study Design We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions. Results Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% (n = 5,374) on all three family members, 26.5% (n = 2,562) in mother and sister(s) only, and 11.6% (n = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00–1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12–2.13) and 1.35 (95% CI: 1.03–1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption. Conclusion This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.

Publisher

Georg Thieme Verlag KG

Subject

Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health

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