Risk factors for premature placental abruption: a retrospective observational comparative study

Abstract

AIM: This study aimed to determine the risk factors for premature placental abruption (PPA). MATERIALS AND METHODS: A retrospective comparative study was conducted at the Republican Perinatal Center of Petrozavodsk. The study group included 106 patients with a confirmed diagnosis of PPA from 2007 to 2017. The control group (comparison) included 106 women without PPA and abnormal placenta. RESULTS: The statistical data analysis revealed the following risk factors of PPA: lack of higher education in the patient (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.280.90); smoking (OR: 3.41, 95% CI: 1.298.97); chronic liver disease (OR: 7.29, 95% CI: 1.6033.06); uterine abnormalities (OR: 8.57, 95% CI: 1.0569.79); and pelvic inflammatory disease (OR: 6.12, 95% CI: 2.5614.62). The effect of chronic hypertension, chronic kidney disease, and anemia on the occurrence of PPA in our study was not significant. CONCLUSION: An increased risk of PPA was found in patients who smoke without higher education with chronic liver disease, uterine abnormalities, and pelvic inflammatory diseases.