Rh(III)-Catalyzed Tandem [4+2] Annulation To Construct Functional Dihydroisoquinolinones

Abstract

AbstractA highly efficient Rh(III)-catalyzed tandem [4+2] annulation to construct functional dihydroisoquinolinone derivatives with an alkenyl side chain by insertion into an N–O bond as an internal oxidation process has been achieved. A wide range of 1,3-dienes as the coupling partners makes this simple methodology even more useful.