Synthesis of Fused Purine Heterocycles via a One-pot Cascade Reaction of a Trisubstituted Pyrimidine-Reference-Cited by-同舟云学术

Synthesis of Fused Purine Heterocycles via a One-pot Cascade Reaction of a Trisubstituted Pyrimidine

Published:2018-05-23 Issue:13 Volume:29 Page:1796-1800
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Fan Huihong¹,Liu Bo¹,Gong Yaling²,Lu Shichao²,Li Dandan²

Affiliation:

1. National Institutes for Food and Drug Control

2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Active Substance Discovery and Drug Ability Evaluation, Institute of Materia Medica

Abstract

A rapid and expedient one-pot procedure for the synthesis of fused purine derivatives from a trisubstituted pyrimidine and various amines has been developed. The tandem substitution reaction and copper(I)-catalyzed annulation exhibited high efficiency. The fused heterocyclic products contain the purine scaffold and may be useful in medicinal chemistry and bioscience.

Funder

National Natural Science Foundation of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1591585.pdf

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