Synthesis of 6,8-diaminopurines via acid-induced cascade cyclization of 5-aminoimidazole precursors and preliminary anticancer evaluation

Author:

Senhorães Nádia R.1,Silva Bruna F.1ORCID,Sousa Raquel12ORCID,Leite Bruna P.1,Gonçalves Jorge M.1,Almeida Paz Filipe A.3ORCID,Pereira-Wilson Cristina24ORCID,Dias Alice M.1ORCID

Affiliation:

1. CQUM – Chemistry Centre, Department of Chemistry, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal

2. CEB – Centre of Biological Engineering, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal

3. CICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal

4. LABBELS – Associate Laboratory, 4710-057, Braga, Portugal

Abstract

Novel 6,8-diaminopurines were synthesized using a fast cascade reaction from easily accessible 5-aminoimidazole precursors. Preliminary assessments suggest that the new entities are excellent candidates for further development as anticancer agents.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

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