Synthesis of 6,8-diaminopurines <i>via</i> acid-induced cascade cyclization of 5-aminoimidazole precursors and preliminary anticancer evaluation-Reference-Cited by-同舟云学术

Synthesis of 6,8-diaminopurines via acid-induced cascade cyclization of 5-aminoimidazole precursors and preliminary anticancer evaluation

Published:2024 Issue:7 Volume:22 Page:1500-1513
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Senhorães Nádia R.¹,Silva Bruna F.¹^ORCID,Sousa Raquel¹²^ORCID,Leite Bruna P.¹,Gonçalves Jorge M.¹,Almeida Paz Filipe A.³^ORCID,Pereira-Wilson Cristina²⁴^ORCID,Dias Alice M.¹^ORCID

Affiliation:

1. CQUM – Chemistry Centre, Department of Chemistry, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal

2. CEB – Centre of Biological Engineering, Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal

3. CICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal

4. LABBELS – Associate Laboratory, 4710-057, Braga, Portugal

Abstract

Novel 6,8-diaminopurines were synthesized using a fast cascade reaction from easily accessible 5-aminoimidazole precursors. Preliminary assessments suggest that the new entities are excellent candidates for further development as anticancer agents.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D3OB01985C

Reference43 articles.

1. The Chemodiversity of Purine as a Constituent of Natural Products

2. A comprehensive review on bioactive fused heterocycles as purine-utilizing enzymes inhibitors

3. The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets

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