T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia-Reference-Cited by-同舟云学术

T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia

Published:2013-10-31 Issue:18 Volume:122 Page:3138-3148
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mardiros Armen¹,Dos Santos Cedric¹,McDonald Tinisha¹,Brown Christine E.¹²,Wang Xiuli¹²,Budde L. Elizabeth¹,Hoffman Lauren¹²,Aguilar Brenda¹²,Chang Wen-Chung¹²,Bretzlaff William¹²,Chang Brenda¹²,Jonnalagadda Mahesh¹²,Starr Renate¹²,Ostberg Julie R.¹²,Jensen Michael C.³,Bhatia Ravi¹,Forman Stephen J.¹

Affiliation:

1. Hematology and Hematopoietic Cell Transplantation and

2. Cancer Immunotherapy & Tumor Immunology, Beckman Research Institute, Beckman Research Institute at City of Hope National Medical Center, Duarte, CA; and

3. Center for Childhood Cancer, Seattle Children’s Research Institute, Seattle, WA

Abstract

Key Points CD123 CAR T cells specifically target CD123+ AML cells. AML patient-derived T cells can be genetically modified to lyse autologous tumor cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/18/3138/1370711/3138.pdf

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