Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

Author:

Döhner Hartmut1,Estey Elihu H.2,Amadori Sergio3,Appelbaum Frederick R.4,Büchner Thomas5,Burnett Alan K.6,Dombret Hervé7,Fenaux Pierre8,Grimwade David9,Larson Richard A.10,Lo-Coco Francesco11,Naoe Tomoki12,Niederwieser Dietger13,Ossenkoppele Gert J.14,Sanz Miguel A.15,Sierra Jorge16,Tallman Martin S.17,Löwenberg Bob18,Bloomfield Clara D.19

Affiliation:

1. Department of Internal Medicine III, University of Ulm, Ulm, Germany;

2. Seattle Cancer Center Alliance, WA;

3. Department of Hematology, Tor Vergata University Hospital, Rome, Italy;

4. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

5. Department of Hematology/Oncology, University of Münster, Münster, Germany;

6. Department of Haematology, University of Wales College of Medicine, Cardiff, United Kingdom;

7. Institut Universitaire d‘Hématologie Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris, Paris, France;

8. Service d'Hématologie Clinique, Hôpital Avicenne, Bobigny, France;

9. Department of Medical and Molecular Genetics, Guy's King's and St. Thomas' School of Medicine, London, United Kingdom;

10. Department of Medicine and Cancer Research Center, University of Chicago, IL;

11. Department of Biopathology, University Tor Vergata and Santa Lucia Foundation at Centro Europeo per la Ricerca sul Cervello, Rome, Italy;

12. Department of Hematology, Nagoya University Hospital, Showa-ku, Japan;

13. Department of Hematology, Oncology and Hemostasis, University of Leipzig, Leipzig, Germany;

14. Department of Haematology, VU University Medical Center, Amsterdam, The Netherlands;

15. Hematology and Bone Marrow Transplant Unit, University Hospital La Fe, Valencia, Spain;

16. Clinical Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;

17. Division of Hematology-Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL;

18. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands; and

19. The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Columbus

Abstract

AbstractIn 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion–based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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