The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

Author:

Vardiman James W.1,Thiele Jüergen2,Arber Daniel A.3,Brunning Richard D.4,Borowitz Michael J.5,Porwit Anna6,Harris Nancy Lee7,Le Beau Michelle M.8,Hellström-Lindberg Eva9,Tefferi Ayalew10,Bloomfield Clara D.11

Affiliation:

1. Department of Pathology, University of Chicago, IL;

2. Institute of Pathology, University of Cologne, Cologne, Germany;

3. Department of Pathology, Stanford University Medical Center, CA;

4. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis;

5. Department of Pathology and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD;

6. Department of Pathology, Karolinska University Hospital, Stockholm, Sweden;

7. Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston;

8. Section of Hematology/Oncology, University of Chicago, IL;

9. Department of Medicine, Karolinska University Hospital, Stockholm, Sweden;

10. Division of Hematology, Mayo Clinic, Rochester, MN; and

11. Comprehensive Cancer Center, The Ohio State University, Columbus

Abstract

Recently the World Health Organization (WHO), in collaboration with the European Association for Haematopathology and the Society for Hematopathology, published a revised and updated edition of the WHO Classification of Tumors of the Hematopoietic and Lymphoid Tissues. The 4th edition of the WHO classification incorporates new information that has emerged from scientific and clinical studies in the interval since the publication of the 3rd edition in 2001, and includes new criteria for the recognition of some previously described neoplasms as well as clarification and refinement of the defining criteria for others. It also adds entities—some defined principally by genetic features—that have only recently been characterized. In this paper, the classification of myeloid neoplasms and acute leukemia is highlighted with the aim of familiarizing hematologists, clinical scientists, and hematopathologists not only with the major changes in the classification but also with the rationale for those changes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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