A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment-Reference-Cited by-同舟云学术

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A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment

Published:2014-09-11 Issue:11 Volume:124 Page:1816-1823
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tomaiuolo Maurizio¹,Stalker Timothy J.¹,Welsh John D.¹²,Diamond Scott L.²,Sinno Talid²,Brass Lawrence F.¹^ORCID

Affiliation:

1. Department of Medicine, and

2. Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA

Abstract

Key Points Hindered diffusion becomes the dominant force of molecular movement in a thrombus. The thrombus core acts as a selective molecular prison.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/11/1816/1468988/1816.pdf

Reference23 articles.

1. Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network.;Stalker;Blood,2013

2. Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse.;Welsh;J Thromb Haemost,2012

3. A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets.;Welsh;Blood,2014

4. Multiscale modeling of platelet adhesion and thrombus growth.;Wang;Ann Biomed Eng,2012

5. Simulation of intrathrombus fluid and solute transport using in vivo clot structures with single platelet resolution.;Voronov;Ann Biomed Eng,2013

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