High prevalence of myeloid neoplasms in adults with non–Langerhans cell histiocytosis

Author:

Papo Matthias1,Diamond Eli L.2,Cohen-Aubart Fleur1,Emile Jean-François34,Roos-Weil Damien5,Gupta Nishant6,Durham Benjamin H.7,Ozkaya Neval7,Dogan Ahmet7,Ulaner Gary A.8,Rampal Raajit9,Kahn Jean-Emmanuel10,Sené Thomas11,Charlotte Frédéric7,Hervier Baptiste12,Besnard Caroline1,Bernard Olivier A.5,Settegrana Catherine13,Droin Nathalie14,Hélias-Rodzewicz Zofia34,Amoura Zahir1,Abdel-Wahab Omar915,Haroche Julien1

Affiliation:

1. Service de Médecine Interne 2, Institut E3M, Centre de Références des Maladies Auto-Immunes et Systémiques Rares, Centre de Référence des Histiocytoses, Hôpital de la Pitié-Salpêtrière, Assistance Publique–Hôpitaux de Paris (AP-HP), Université Pierre et Marie Curie, Paris, France;

2. Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY;

3. EA4340, Versailles University, Paris-Saclay University, Boulogne, France;

4. Pathology Service, Hôpital universitaire Ambroise Paré, AP-HP, Boulogne, France;

5. UMR1170, INSERM and Institute Gustave Roussy, Villejuif, France;

6. Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH;

7. Department of Pathology,

8. Department of Radiology, and

9. Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY;

10. Department of Internal Medicine, Foch Hospital, Suresnes, France;

11. Department of Internal Medicine, Croix Saint-Simon Hospital, Paris, France;

12. Department of Internal Medicine and Immunology, and

13. Department of Biological Hematology, University Hospital La Pitié Salpêtrière, AP-HP, Paris, France;

14. Gustave Roussy, Paris-Saclay University, Genomic Platform UMS AMMICA, Villejuif, France; and

15. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY

Abstract

Key Points Some 10.1% of adults with non–Langerhans cell histiocytosis have a concomitant myeloid neoplasm with each often harboring distinct mutations. The presence of distinct kinase mutations in histiocytosis and myeloid neoplasms resulted in discordant responses to targeted therapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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