Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis-Reference-Cited by-全球学者库

Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis

Published:2014-11-06 Issue:19 Volume:124 Page:3007-3015
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chakraborty Rikhia¹,Hampton Oliver A.²³,Shen Xiaoyun¹,Simko Stephen J.¹⁴,Shih Albert¹,Abhyankar Harshal¹,Lim Karen Phaik Har¹⁵,Covington Kyle R.²³,Trevino Lisa²³,Dewal Ninad²³,Muzny Donna M.³,Doddapaneni Harshavardhan³,Hu Jianhong³,Wang Linghua²³,Lupo Philip J.¹⁴,Hicks M. John¹⁴⁶,Bonilla Diana L.⁷,Dwyer Karen C.⁷,Berres Marie-Luise⁸⁹¹⁰,Poulikakos Poulikos I.⁸⁹¹¹,Merad Miriam⁸⁹¹⁰,McClain Kenneth L.¹⁴,Wheeler David A.²³,Allen Carl E.¹⁴⁵,Parsons D. Williams¹²³⁴⁵

Affiliation:

1. Texas Children’s Cancer Center, Texas Children’s Hospital, Houston, TX;

2. Department of Molecular and Human Genetics,

3. Human Genome Sequencing Center,

4. Division of Pediatric Hematology-Oncology, Department of Pediatrics,

5. Program in Translational Biology and Molecular Medicine, and

6. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX;

7. Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX; and

8. Department of Oncological Sciences,

9. Tisch Cancer Institute,

10. Immunology Institute, and

11. Department of Dermatology, Icahn School of Medicine, New York, NY

Abstract

Key Points Recurrent somatic mutations in MAP2K1 were identified in 33% of LCH lesions with wild-type BRAF. The mutant MAPK kinase 1 proteins activate ERK. The ability of MAPK pathway inhibitors to suppress MAPK kinase and ERK phosphorylation in vitro was dependent on the specific LCH mutation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/19/3007/1381467/3007.pdf

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