Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis

Author:

Gadner Helmut1,Minkov Milen1,Grois Nicole1,Pötschger Ulrike1,Thiem Elfriede1,Aricò Maurizio2,Astigarraga Itziar3,Braier Jorge4,Donadieu Jean5,Henter Jan-Inge6,Janka-Schaub Gritta7,McClain Kenneth L.8,Weitzman Sheila9,Windebank Kevin10,Ladisch Stephan11

Affiliation:

1. Children’s Cancer Research Institute and St. Anna Children’s Hospital, Vienna, Austria;

2. Department of Hematology-Oncology, University Children’s Hospital, Florence, Italy;

3. Hospital Universitario Cruces, Bilbao, Spain;

4. Hospital Nacional de Pediatria J. Garrahan, Buenos Aires, Argentina;

5. Hospital Trousseau, Paris, France;

6. Childhood Cancer Research Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden;

7. Department of Hematology and Oncology, University Medical Center, Hamburg, Germany;

8. Texas Children’s Cancer and Hematology Centers, Houston, TX;

9. Hospital for Sick Children, Division of Hematology/Oncology, Toronto, Ontario, Canada;

10. Newcastle University, Newcastle, United Kingdom; and

11. Children’s Research Institute, Children’s National Medical Center, Washington DC

Abstract

Key Points Reactivations of multisystem Langerhans cell histiocytosis (MS-LCH) are reduced by prolonging initial chemotherapy. The previously high mortality of high-risk (risk-organ–positive) MS-LCH in children has been markedly reduced.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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