Interleukin 27 inhibits cytotoxic T-lymphocyte-mediated platelet destruction in primary immune thrombocytopenia-Reference-Cited by-同舟云学术

Interleukin 27 inhibits cytotoxic T-lymphocyte-mediated platelet destruction in primary immune thrombocytopenia

Published:2014-11-20 Issue:22 Volume:124 Page:3316-3319
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhou Hai¹,Qiu Ji-hua¹,Wang Tong²,Yu Ying-yi¹,Liu Xue-na¹,Li Xin¹,Wang Ya-wen¹,Hou Yu¹,Li Li-zhen¹,Liu Xin-guang²,Hou Ming¹³,Peng Jun¹³

Affiliation:

1. Department of Hematology,

2. Cancer Center, and

3. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, China

Abstract

Key Points IL-27 inhibits CTL cytotoxicity toward autologous platelets via decreasing granzyme B expression in ITP.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/22/3316/1465147/3316.pdf

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4. Preferential splenic CD8(+) T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia.;Audia;Blood,2013

5. Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia.;Guo;Blood,2014

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