Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia-Reference-Cited by-同舟云学术

Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia

Published:2014-01-16 Issue:3 Volume:123 Page:422-427
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Guo Li¹²³,Yang Lei¹²,Speck Edwin R.¹²⁴,Aslam Rukhsana¹²⁴,Kim Michael¹²,McKenzie Christopher G. J.¹²⁴,Lazarus Alan H.¹²³⁴⁵,Ni Heyu¹²³⁵⁶,Hou Ming⁷,Freedman John¹⁵⁶,Semple John W.¹²³⁴⁵

Affiliation:

1. The Toronto Platelet Immunobiology Group,

2. Keenan Research Centre for Biomedical Sciences, St. Michael's Hospital, and

3. Institute of Medical Science, University of Toronto, Toronto, ON, Canada;

4. Canadian Blood Services, Toronto, ON, Canada;

5. Department of Medicine, and

6. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;

7. Cancer Center, Qilu Hospital, Shandong University, Jinan, China; and

Abstract

Key Points Allogeneic platelet MHC class I transfusions can both prevent and/or alleviate anti-CD61 (GPIIIa) T-cell–mediated ITP. The transfusions reverse abnormal bone marrow megakaryocyte histology and inhibit CD61-induced cytotoxicity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/3/422/1377868/422.pdf

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5. The role of the reticuloendothelial system in the pathogenesis of idiopathic thrombocytopenic purpura.;Shulman;Trans Assoc Am Physicians,1965

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