International consensus report on the investigation and management of primary immune thrombocytopenia

Author:

Provan Drew1,Stasi Roberto2,Newland Adrian C.1,Blanchette Victor S.3,Bolton-Maggs Paula4,Bussel James B.5,Chong Beng H.6,Cines Douglas B.7,Gernsheimer Terry B.8,Godeau Bertrand9,Grainger John10,Greer Ian11,Hunt Beverley J.12,Imbach Paul A.13,Lyons Gordon14,McMillan Robert15,Rodeghiero Francesco16,Sanz Miguel A.17,Tarantino Michael18,Watson Shirley19,Young Joan20,Kuter David J.21

Affiliation:

1. Department of Haematology, Barts and The London School of Medicine and Dentistry, London, United Kingdom;

2. Department of Haematology, St George's Healthcare, National Health Service (NHS) Trust, London, United Kingdom;

3. Division of Haematology/Oncology, University of Toronto, The Hospital for Sick Children, Toronto, ON;

4. Department of Clinical Haematology, Manchester Royal Infirmary, Manchester, United Kingdom;

5. Department of Pediatrics, New York Hospital, New York, NY;

6. St George Clinical School, University of New South Wales, Sydney, Australia;

7. Department of Pathology and Laboratory, Hospital of the University of Pennsylvania, Philadelphia;

8. Puget Sound Blood Center and The University of Washington, Seattle;

9. Service de Médecine Interne, Assistance-Publique Hôpitaux de Paris, Paris, France;

10. Royal Manchester Children's Hospital, Manchester, United Kingdom;

11. Hull York Medical School, University of York, York, United Kingdom;

12. Thrombosis & Haemostasis, King's College, London, and Departments of Haematology, Pathology, and Rheumatology, Guy's & St Thomas' National Health Service (NHS) Foundation Trust, London, United Kingdom;

13. University Children's Hospital, Basel, Switzerland;

14. Obstetric Anaesthesia, St James' University Hospital, Leeds, United Kingdom;

15. The Scripps Research Institute, La Jolla, CA;

16. Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy;

17. Department of Haematology, Hospital Universitario La Fe, Valencia, Spain;

18. Comprehensive Bleeding Disorders Center, Peoria, IL;

19. ITP Support Association, Bedford, United Kingdom;

20. Platelet Disorder Support Association, Rockville, MD; and

21. Department of Hematology, Massachusetts General Hospital and Harvard Medical School, Boston

Abstract

AbstractPreviously published guidelines for the diagnosis and management of primary immune thrombocytopenia (ITP) require updating largely due to the introduction of new classes of therapeutic agents, and a greater understanding of the disease pathophysiology. However, treatment-related decisions still remain principally dependent on clinical expertise or patient preference rather than high-quality clinical trial evidence. This consensus document aims to report on new data and provide consensus-based recommendations relating to diagnosis and treatment of ITP in adults, in children, and during pregnancy. The inclusion of summary tables within this document, supported by information tables in the online appendices, is intended to aid in clinical decision making.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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