Preferential splenic CD8+ T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia-Reference-Cited by-同舟云学术

Preferential splenic CD8+ T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia

Published:2013-10-03 Issue:14 Volume:122 Page:2477-2486
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Audia Sylvain¹²³,Samson Maxime¹²³,Mahévas Matthieu⁴,Ferrand Christophe¹,Trad Malika¹³,Ciudad Marion¹³,Gautheron Alexandrine¹³,Seaphanh Famky¹³,Leguy Vanessa²,Berthier Sabine²,Salles Bruno⁵,Martin Laurent¹³⁶,Lorcerie Bernard²³,Ortega-Deballon Pablo³⁷,Facy Olivier³⁷,Caillot Denis⁸,Soudry-Faure Agnès⁹,Michel Marc⁴,Godeau Bertrand⁴,Larmonier Nicolas¹⁰,Saas Philippe¹,Janikashvili Nona¹³,Bonnotte Bernard¹²³

Affiliation:

1. Centre de Recherche, National de la Santé et de la Recherche Médicale 1098, University of Franche-Comté, Besançon, France;

2. Department of Internal Medicine and Clinical Immunology, Competence Center for Auto-Immune Cytopenia, University Hospital, Dijon, France;

3. Faculty of Medicine, University of Burgundy, Dijon, France;

4. Department of Internal Medicine, Reference Center for Auto-Immune Cytopenia, University Hospital, Créteil, France;

5. Department of Hematology and Oncology, Chalon/Saône, France;

6. Department of Pathology and Cytology,

7. Department of Surgery,

8. Department of Hematology, and

9. Department of Clinical Research, University Hospital of Dijon, Dijon, France; and

10. Department of Pediatrics, Steele Children's Research Center, Department of Immunobiology, BIO5 Institute and Arizona Cancer Center, University of Arizona, Tucson, AZ

Abstract

Key Points Activated CD8+ T cells are preferentially found in the spleen of ITP patients who are nonresponders to rituximab.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/14/2477/1371177/2477.pdf

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