Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD-Reference-Cited by-同舟云学术

Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD

Published:2015-01-15 Issue:3 Volume:125 Page:570-580
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hechinger Anne-Kathrin¹,Smith Benjamin A. H.¹,Flynn Ryan²,Hanke Kathrin¹,McDonald-Hyman Cameron²,Taylor Patricia A.²,Pfeifer Dietmar¹,Hackanson Björn¹,Leonhardt Franziska¹³,Prinz Gabriele¹,Dierbach Heide¹,Schmitt-Graeff Annette⁴,Kovarik Jiri⁵,Blazar Bruce R.²,Zeiser Robert¹

Affiliation:

1. Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, Albert-Ludwigs-University, Freiburg, Germany;

2. Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN;

3. Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany;

4. Department of Pathology, Freiburg University Medical Center, Albert-Ludwigs-University, Freiburg, Germany; and

5. Novartis Institutes for Biomedical Research, Basel, Switzerland

Abstract

Key Points Monoclonal antibody blockade of the common γ chain attenuates acute and chronic GVHD. Common γ-chain cytokines increase granzyme B levels in CD8 T cells, which are reduced upon CD132 blockade in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/3/570/1345018/570.pdf

Reference49 articles.

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