MiR-146a regulates the TRAF6/TNF-axis in donor T cells during GVHD-Reference-Cited by-同舟云学术

MiR-146a regulates the TRAF6/TNF-axis in donor T cells during GVHD

Published:2014-10-16 Issue:16 Volume:124 Page:2586-2595
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Stickel Natalie¹²³,Prinz Gabriele¹,Pfeifer Dietmar¹,Hasselblatt Peter⁴,Schmitt-Graeff Annette⁵,Follo Marie¹,Thimme Robert⁴,Finke Jürgen¹,Duyster Justus¹,Salzer Ulrich⁶⁷,Zeiser Robert¹⁸

Affiliation:

1. Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center,

2. Spemann Graduate School of Biology and Medicine, and

3. Faculty of Biology, Albert Ludwigs University Freiburg, Freiburg, Germany;

4. Department of Medicine, Clinic for Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, and

5. Department of Pathology, Freiburg University Medical Center, Albert Ludwigs University Freiburg, Freiburg, Germany;

6. Center for Chronic Immunodeficiency,

7. Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany; and

8. Centre for Biological Signaling Studies, Albert Ludwigs University Freiburg, Freiburg, Germany

Abstract

Key Points This study deciphers the regulatory role of miR-146a during GVHD in mice. In humans, the minor genotype of the SNP rs2910164, which reduces expression of miR-146a, was associated with higher GVHD severity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/16/2586/1380941/2586.pdf

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