Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100-Reference-Cited by-同舟云学术

Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100

Published:2013-04-25 Issue:17 Volume:121 Page:3307-3318
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Leonhardt Franziska¹²,Grundmann Sebastian³,Behe Martin⁴⁵,Bluhm Franziska³²,Dumont Rebecca A.⁴⁶,Braun Friederike⁴,Fani Melpomeni⁴⁷,Riesner Katarina⁸,Prinz Gabriele¹,Hechinger Anne-Kathrin¹²,Gerlach Ulrike V.⁹,Dierbach Heide¹,Penack Olaf⁸,Schmitt-Gräff Annette⁹,Finke Jürgen¹,Weber Wolfgang A.⁴,Zeiser Robert¹¹⁰

Affiliation:

1. Department of Hematology and Oncology,

2. Department of Biology,

3. Department of Cardiology and Angiology, and

4. Department of Nuclear Medicine, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Freiburg, Germany;

5. Department of Nuclear Medicine, Universitätsspital Zürich, Zürich, Switzerland;

6. Department of Radiology, David Geffen School of Medicine at University of California, Los Angeles, CA;

7. Department of Nuclear Medicine, Universitätsspital Basel, Basel, Switzerland;

8. Department of Hematology, Oncology and Tumorimmunology, Charité University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany;

9. Department of Pathology, Freiburg University Medical Center, and

10. Centre for Biological Signaling Studies, Albert-Ludwigs-University of Freiburg, Freiburg, Germany

Abstract

Key Points Our data from the mouse model and patients indicate that inflammatory neovascularization during GvHD is targetable via αv integrin. We identify a negative regulation of GvHD-related neovascularization by miR-100.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/17/3307/1365395/3307.pdf

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