Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection-Reference-Cited by-同舟云学术

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection

Published:2014-01-02 Issue:1 Volume:123 Page:61-69
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Didigu Chuka A.¹,Wilen Craig B.¹,Wang Jianbin²,Duong Jennifer²,Secreto Anthony J.³,Danet-Desnoyers Gwenn A.³,Riley James L.⁴,Gregory Phillip D.²,June Carl H.⁴,Holmes Michael C.²,Doms Robert W.¹⁵

Affiliation:

1. Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA;

2. Sangamo Biosciences, Richmond, CA;

3. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA;

4. Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA; and

5. Department of Pathology, The Children’s Hospital of Philadelphia, Philadelphia, PA

Abstract

Key PointsZinc-finger nucleases simultaneously and permanently inactivate HIV coreceptors ccr5 and cxcr4 resulting in HIV-resistant CD4+ T cells. These HIV-resistant cells may be used to achieve a functional cure for HIV in humans.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/1/61/1373245/61.pdf

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