Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay-Reference-Cited by-同舟云学术

Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay

Published:2014-02-20 Issue:8 Volume:123 Page:e11-e22
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lordkipanidzé Marie¹,Lowe Gillian C.¹,Kirkby Nicholas S.²,Chan Melissa V.²,Lundberg Martina H.²,Morgan Neil V.¹,Bem Danai¹,Nisar Shaista P.³,Leo Vincenzo C.⁴,Jones Matthew L.⁵,Mundell Stuart J.³,Daly Martina E.⁴,Mumford Andrew D.⁵,Warner Timothy D.²,Watson Steve P.¹

Affiliation:

1. Centre for Cardiovascular Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom;

2. The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom;

3. School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom;

4. Department of Cardiovascular Science, University of Sheffield Medical School, University of Sheffield, Sheffield, United Kingdom; and

5. Bristol Heart Institute and School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

Abstract

Key Points The Optimul 96-well platelet aggregation assay has high levels of sensitivity and specificity for detecting platelet defects. The requirement for a small volume of blood, straightforward nature, and speed make Optimul a promising screening test in bleeding patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/8/e11/1379291/e11.pdf

Reference36 articles.

1. Genotyping and phenotyping of platelet function disorders.;Watson;J Thromb Haemost,2013

2. Platelet function testing in cardiovascular diseases.;Michelson;Circulation,2004

3. Advances in platelet function testing assessing bleeding complications in patients with coronary artery disease.;Rollini;Platelets,2012

4. Testing platelet function.;Harrison;Hematol Oncol Clin North Am,2013

5. Shear-induced platelet aggregation in aspirin-treated patients: initial experience with the novel PlaCor PRT device.;Würtz;Thromb Res,2012

Cited by 60 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The study of platelet aggregation using a microtiter plate reader ‒ methodological considerations;Pharmacological Reports;2024-03-05

2. Factors that modulate platelet reactivity as measured by 5 assay platforms in 3429 individuals;Research and Practice in Thrombosis and Haemostasis;2024-03

3. The Coagulology Section of the Polish Societyof Laboratory Diagnostics recommendations on the plateletreactivity test. 2023;Diagnostyka Laboratoryjna;2023-12-22

4. Classic Light Transmission Platelet Aggregometry: Do We Still Need it?;Hämostaseologie;2023-12-08

5. High-throughput microfluidic blood testing to phenotype genetically linked platelet disorders: an aid to diagnosis;Blood Advances;2023-10-13