Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia-Reference-Cited by-同舟云学术

Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia

Published:2017-03-09 Issue:10 Volume:129 Page:1333-1342
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bochtler Tilmann¹²,Granzow Martin³,Stölzel Friedrich⁴,Kunz Christina⁵,Mohr Brigitte⁴,Kartal-Kaess Mutlu¹³⁶,Hinderhofer Katrin³,Heilig Christoph E.¹²,Kramer Michael⁴,Thiede Christian⁴,Endris Volker⁷,Kirchner Martina⁷,Stenzinger Albrecht⁷,Benner Axel⁵,Bornhäuser Martin⁴,Ehninger Gerhard⁴,Ho Anthony D.²,Jauch Anna³,Krämer Alwin¹²

Affiliation:

1. Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center,

2. Department of Internal Medicine V, and

3. Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany;

4. Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany;

5. Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany; and

6. Department of Pediatric Oncology, Hematology and Immunology, and

7. Institute of Pathology, University of Heidelberg, Heidelberg, Germany

Abstract

Key Points Marker chromosomes are frequently found in AML, particularly among aneuploid adverse-risk karyotypes and confer a poor prognosis. About one-third of marker and ring chromosome karyotypes arise from chromothripsis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/10/1333/1399134/blood738161.pdf

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