Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2

Author:

Jäckel Sven12ORCID,Kiouptsi Klytaimnistra1,Lillich Maren1,Hendrikx Tim34,Khandagale Avinash1,Kollar Bettina1,Hörmann Nives1,Reiss Cora1,Subramaniam Saravanan1,Wilms Eivor1,Ebner Katharina5,Brühl Marie-Luise von6,Rausch Philipp7,Baines John F.78,Haberichter Sandra91011,Lämmle Bernhard112,Binder Christoph J.34,Jurk Kerstin12ORCID,Ruggeri Zaverio M.13,Massberg Steffen6,Walter Ulrich12,Ruf Wolfram1214,Reinhardt Christoph12ORCID

Affiliation:

1. Center for Thrombosis and Hemostasis, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Germany;

2. German Center for Cardiovascular Research, Partner Site Rhein-Main, Mainz, Germany;

3. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria;

4. Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria;

5. III. Medical Clinic and Polyclinic, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Germany;

6. Medical Clinic and Polyclinic I, Clinic of the Ludwig-Maximilians-University Munich, Munich, Germany;

7. Max Planck Institute for Evolutionary Biology, Plön, Germany;

8. Institute for Experimental Medicine, University of Kiel, Kiel, Germany;

9. Diagnostic Laboratories and

10. Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI;

11. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI;

12. Clinic of Hematology and Central Hematology Laboratory, Inselspital University Hospital, Bern, Switzerland; and

13. Department of Molecular Medicine and

14. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA

Abstract

Key Points VWF synthesis in liver endothelial cells is regulated by gut microbiota through TLR2 signaling. Reduced plasma VWF levels in GF and Tlr2−/− mice cause reduced thrombus formation at the ligation-injured carotid artery.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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