Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

Author:

Bishop David C.1234ORCID,Clancy Leighton E.15,Simms Renee125,Burgess Jane125,Mathew Geetha15ORCID,Moezzi Leili15,Street Janine A.15,Sutrave Gaurav1234,Atkins Elissa3,McGuire Helen M.678ORCID,Gloss Brian S.1,Lee Koon12ORCID,Jiang Wei12ORCID,Maddock Karen3,McCaughan Georgia23ORCID,Avdic Selmir15,Antonenas Vicki5,O’Brien Tracey A.91011,Shaw Peter J.1213ORCID,Irving David O.1415ORCID,Gottlieb David J.12345,Blyth Emily12345ORCID,Micklethwaite Kenneth P.12345

Affiliation:

1. Westmead Institute for Medical Research, Sydney, NSW, Australia;

2. Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia;

3. Department of Haematology , Westmead Hospital, Sydney, NSW, Australia;

4. Blood Transplant and Cell Therapies Program, Westmead Hospital, Sydney, NSW, Australia;

5. Blood Transplant and Cell Therapies Laboratory, NSW Health Pathology–ICPMR Westmead, Sydney, NSW, Australia;

6. Ramaciotti Facility for Human Systems Biology, University of Sydney, Sydney, NSW, Australia;

7. Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia;

8. School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia;

9. Children’s Cancer Institute, Sydney, NSW, Australia;

10. School of Women’s & Children’s Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia;

11. Kids Cancer Centre, Sydney Children’s Hospital, Sydney, NSW, Australia;

12. BMT Services, Children’s Hospital at Westmead, Sydney, NSW, Australia;

13. Discipline of Child and Adolescent Health, The Children’s Hospital at Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia;

14. Australian Red Cross Lifeblood, Sydney, NSW, Australia; and

15. Faculty of Nursing, Midwifery & Health, University of Technology, Sydney, NSW, Australia

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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