Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

Author:

Kochenderfer James N.1,Dudley Mark E.2,Carpenter Robert O.1,Kassim Sadik H.2,Rose Jeremy J.1,Telford William G.1,Hakim Frances T.1,Halverson David C.1,Fowler Daniel H.1,Hardy Nancy M.1,Mato Anthony R.3,Hickstein Dennis D.1,Gea-Banacloche Juan C.1,Pavletic Steven Z.1,Sportes Claude1,Maric Irina4,Feldman Steven A.2,Hansen Brenna G.1,Wilder Jennifer S.5,Blacklock-Schuver Bazetta1,Jena Bipulendu6,Bishop Michael R.7,Gress Ronald E.1,Rosenberg Steven A.2

Affiliation:

1. Experimental Transplantation and Immunology Branch and

2. Surgery Branch, National Cancer Institute, Bethesda, MD;

3. John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ;

4. Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD;

5. Clinical Research Directorate Science Applications International Corporation-Frederick Inc., National Cancer Institute Frederick, Frederick, MD;

6. University of Texas, MD Anderson Cancer Center, Houston, TX; and

7. Section of Hematology/Oncology, University of Chicago, Chicago, IL

Abstract

Key Points Donor-derived anti-CD19-CAR T cells cause regressions of refractory malignancies after allogeneic transplantation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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