Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study-Reference-Cited by-同舟云学术

Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study

Published:2013-10-24 Issue:17 Volume:122 Page:2965-2973
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cruz Conrad Russell Y.¹,Micklethwaite Kenneth P.¹,Savoldo Barbara¹,Ramos Carlos A.¹,Lam Sharon¹,Ku Stephanie¹,Diouf Oumar¹,Liu Enli¹,Barrett A. John²,Ito Sawa²,Shpall Elizabeth J.³,Krance Robert A.¹⁴,Kamble Rammurti T.¹⁴,Carrum George¹⁴,Hosing Chitra M.³,Gee Adrian P.¹,Mei Zhuyong¹,Grilley Bambi J.¹,Heslop Helen E.¹⁴,Rooney Cliona M.¹,Brenner Malcolm K.¹⁴,Bollard Catherine M.¹⁴,Dotti Gianpietro¹

Affiliation:

1. Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;

2. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;

3. University of Texas MD Anderson Cancer Center, Houston, TX; and

4. The Methodist Hospital, Houston, TX

Abstract

Key Points Allogeneic CD19-CAR VSTs are well tolerated by patients with relapsed B-cell malignancies post-HSCT. At periods of CD19-CAR VST persistence, these cells demonstrate antitumor activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/17/2965/1370392/2965.pdf

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