Future Directions for Dementia Risk Reduction and Prevention Research: An International Research Network on Dementia Prevention Consensus

Author:

Anstey Kaarin J.12,Peters Ruth12,Zheng Lidan12,Barnes Deborah E.345,Brayne Carol6,Brodaty Henry7,Chalmers John8,Clare Linda9,Dixon Roger A.10,Dodge Hiroko111213,Lautenschlager Nicola T.1415,Middleton Laura E.16,Qiu Chengxuan17,Rees Glenn18,Shahar Suzana19,Yaffe Kristine34520

Affiliation:

1. UNSW Aging Futures Institute, School of Psychology, University of New South Wales, Sydney, NSW, Australia

2. Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia

3. Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA

4. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA

5. San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA

6. Cambridge Public Health, University of Cambridge, Forvie Site, Cambridge, UK

7. Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia

8. Faculty of Medicine, The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia

9. College of Medicine and Health, University of Exeter, St Luke’s Campus, Exeter, UK

10. Neuroscience and Mental Health Institute, Department of Psychology, University of Alberta, Edmonton, AB, Canada

11. Layton Aging and Alzheimer’s Disease Center, Department of Neurology, Oregon Health & Science University, Portland, OR, USA

12. Michigan Alzheimer’s Disease Center, Department of Neurology, University of Michigan, Ann Arbor, MI, USA

13. Michigan Alzheimer’s Disease Center, University of Michigan, Ann Arbor, MI, USA

14. Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia

15. NorthWestern Mental Health, Royal Melbourne Hospital, Parkville, VIC, Australia

16. Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada

17. Aging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden

18. Alzheimer’s Disease International, London, UK

19. Center for Healthy Ageing & Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia

20. Department of Neurology, University of California, San Francisco, San Francisco, CA, USA

Abstract

In the past decade a large body of evidence has accumulated on risk factors for dementia, primarily from Europe and North America. Drawing on recent integrative reviews and a consensus workshop, the International Research Network on Dementia Prevention developed a consensus statement on priorities for future research. Significant gaps in geographical location, representativeness, diversity, duration, mechanisms, and research on combinations of risk factors were identified. Future research to inform dementia risk reduction should fill gaps in the evidence base, take a life-course, multi-domain approach, and inform population health approaches that improve the brain-health of whole communities.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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