Umbrella review and Delphi study on modifiable factors for dementia risk reduction-Reference-Cited by-同舟云学术

Umbrella review and Delphi study on modifiable factors for dementia risk reduction

Published:2023-12-30 Issue: Volume: Page:
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Rosenau Colin¹,Köhler Sebastian¹,Soons Lion M.¹,Anstey Kaarin J.²³⁴,Brayne Carol⁵,Brodaty Henry⁶,Engedal Knut⁷,Farina Francesca R.⁸,Ganguli Mary⁹,Livingston Gill¹⁰,Lyketsos Constantine G.¹¹,Mangialasche Francesca¹²¹³,Middleton Laura E.¹⁴¹⁵,Rikkert Marcel G. M. Olde¹⁶¹⁷,Peters Ruth⁴¹⁸¹⁹,Sachdev Perminder S.⁶,Scarmeas Nikolaos²⁰²¹,Salbæk Geir⁷²²²³,van Boxtel Martin P. J.¹,Deckers Kay¹

Affiliation:

1. Alzheimer Centrum Limburg Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience (MHeNs) Maastricht University Maastricht the Netherlands

2. School of Psychology University of New South Wales Kensington New South Wales Australia

3. Neuroscience Research Australia (NeuRA) Sydney New South Wales Australia

4. UNSW Ageing Futures Institute Kensington New South Wales Australia

5. Cambridge Public Health University of Cambridge Cambridge UK

6. Centre for Healthy Brain Ageing (CHeBA) Discipline of Psychiatry and Mental Health School of Clinical Medicine University of New South Wales Sydney New South Wales Australia

7. Norwegian National Centre for Ageing and Health Vestfold Hospital Trust Tønsberg Norway

8. Feinberg School of Medicine Department of Medical Social Sciences Northwestern University Chicago Illinois USA

9. Departments of Psychiatry Neurology and Epidemiology School of Medicine and School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA

10. Division of Psychiatry University College London London UK

11. Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease Johns Hopkins Bayview Johns Hopkins Medicine Baltimore Maryland USA

12. Division of Clinical Geriatrics Department of Neurobiology Care Sciences and Society Center for Alzheimer Research Karolinska Institutet Stockholm Sweden

13. Theme Inflammation and Aging Medical Unit Aging Karolinska University Hospital Stockholm Sweden

14. Department of Kinesiology and Health Sciences University of Waterloo Waterloo Ontario Canada

15. Schlegel‐UW Research Institute for Aging Waterloo Ontario Canada

16. Department of Geriatric Medicine Radboud University Medical Center Nijmegen the Netherlands

17. Radboudumc Alzheimer Center Donders Center of Medical Neurosciences Nijmegen the Netherlands

18. The George Institute for Global Health Newtown New South Wales Australia

19. School of Biomedical Sciences University of New South Wales Kensington New South Wales Australia

20. 1st Department of Neurology Aiginition Hospital National and Kapodistrian University of Athens Medical School Athens Greece

21. Department of Neurology Columbia University New York New York USA

22. Department of Geriatric Medicine Oslo University Hospital Oslo Norway

23. Institute of Clinical Medicine University of Oslo Oslo Norway

Abstract

AbstractA 2013 systematic review and Delphi consensus study identified 12 modifiable risk and protective factors for dementia, which were subsequently merged into the “LIfestyle for BRAin health” (LIBRA) score. We systematically evaluated whether LIBRA requires revision based on new evidence. To identify modifiable risk and protective factors suitable for dementia risk reduction, we combined an umbrella review of systematic reviews and meta‐analyses with a two‐round Delphi consensus study. The review of 608 unique primary studies and opinions of 18 experts prioritized six modifiable factors: hearing impairment, social contact, sleep, life course inequalities, atrial fibrillation, and psychological stress. Based on expert ranking, hearing impairment, social contact, and sleep were considered the most suitable candidates for inclusion in updated dementia risk scores. As such, the current study shows that dementia risk scores need systematic updates based on emerging evidence. Future studies will validate the updated LIBRA score in different cohorts.HIGHLIGHTS

An umbrella review was combined with opinions of 18 dementia experts.

Various candidate targets for dementia risk reduction were identified.

Experts prioritized hearing impairment, social contact, and sleep.

Re‐assessment of dementia risk scores is encouraged.

Future work should evaluate the predictive validity of updated risk scores.

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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