Author:
Counsell Andrew J,Jones Angus T,Todd Matthew H,Rutledge Peter J
Abstract
An efficient protocol for the direct synthesis of N-tetraalkylated derivatives of the azamacrocycles cyclam and cyclen has been developed, using a partially miscible aqueous–organic solvent system with propargyl bromide, benzyl bromide, and related halides. The method works most effectively when the reaction mixture is shaken, not stirred. A crystal structure of the N-tetrapropargyl cyclam derivative 1,4,8,11-tetra(prop-2-yn-1-yl)-1,4,8,11-tetraazacyclotetradecane diperchlorate is reported.
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Interaction of C-Alkylsubstituted-1,4,8,11-tetraazacyclotetradeca-4,11-dienes with Carboxylic Acid Halides as a New Method for the Synthesis of C- and N-Acyl-2,3,6,7-tetrahydro-1,4-diazepines;Russian Journal of General Chemistry;2022-12
2. Ten-Membered Rings or Lager With One or More Nitrogen Atoms;Comprehensive Heterocyclic Chemistry IV;2022
3. Dinuclear Copper(I) Thiodiacetate Complex-Mediated Expeditious Synthesis of the Chlorine-Containing Cyclen-Cored 36-Glucose-Coated Glycodendrimer;Journal of Chemistry;2021-10-27
4. The Oxo-Wall Remains Intact: A Tetrahedrally Distorted Co(IV)–Oxo Complex;Journal of the American Chemical Society;2021-10-05
5. Synthesis and structural characterization of N,N',N'',N'''-tetrasubstituted cyclams;Chemistry of Heterocyclic Compounds;2021-08