Reaction of <i>c</i>-alkyl-substituted 1,4,8,11-tetraazacyclotetradeca-4,11-dienes with carboxylic acid halides as a new method for the synthesis of <i>c</i>- and <i>N</i>-acyl-2,3,6,7-tetrahydro-1,4-diazepines

Abstract

The reactions of 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene with acetic and tetrafluorobenzoic acids halides produce C - and N -acyl-substituted 1,4-diazepines. Their structure was characterized by IR, 1H, and 13C NMR spectroscopy using two-dimensional experiments 1H-13C HMQC, HMBC, and 1H-1H COSY.