Dinuclear Copper(I) Thiodiacetate Complex-Mediated Expeditious Synthesis of the Chlorine-Containing Cyclen-Cored 36-Glucose-Coated Glycodendrimer

Author:

Agrahari Anand K.1,Kumar Sunil1,Sharma Anindra2ORCID,Tiwari Vinod K.1ORCID

Affiliation:

1. Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India

2. Department of Chemistry, A.P.S.M. College-Barauni, LNM University, Darbhanga, India

Abstract

High-sugar-tethered glycodendrimers are a remarkable tool in glycobiology for the investigation of carbohydrate-protein interaction using its multivalency property. An enthralling double-stage convergent synthetic approach was selected to build a novel class of chlorine-containing glucose-coated dendrimers using an efficient click catalyst ‘dinuclear copper(I) thiodiacetate complex.’ In this context, cyclen core was developed through a divergent approach, while the glucodendron was developed via a convergent approach independently. Both azide-alkyne partners were coupled through a modular copper azide-alkyne cycloaddition (CuAAC) strategy to afford a high yield of the desired 36-glucose-coated glycodendrimer. The synthesized glycodendrimer has been elucidated by NMR, gel permeation chromatography (GPC), and IR spectral analysis.

Funder

Council of Scientific and Industrial Research

Publisher

Hindawi Limited

Subject

General Chemistry

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