Molecular Pathogenesis of Diffuse Large B-Cell Lymphoma-Reference-Cited by-同舟云学术

Molecular Pathogenesis of Diffuse Large B-Cell Lymphoma

Published:2005-09-10 Issue:26 Volume:23 Page:6351-6357
ISSN:0732-183X
Container-title:Journal of Clinical Oncology
language:en
Short-container-title:JCO

Author:

Lossos Izidore S.¹

Affiliation:

1. From the Sylvester Comprehensive Cancer Center, Division of Hematology-Oncology, Department of Medicine, Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL

Abstract

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous clinicopathologic entity accounting for 30% of non-Hodgkin's lymphomas. The pathogenesis of DLBCL is complex and heterogeneous. Recent studies using analysis of global gene expression with DNA microarrays and the classical molecular approaches demonstrate presence of several DLBCL subtypes characterized by different cells of origin, cytogenetic and molecular aberrations, and distinct pathogenesis. This review summarizes the progress in understanding of DLBCL biology and presents a state-of-the-art overview of DLBCL molecular pathogenesis.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

Link

http://ascopubs.org/doi/pdfdirect/10.1200/JCO.2005.05.012

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