MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription-Reference-Cited by-同舟云学术

MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription

Published:2023-04-19 Issue: Volume: Page:
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Author:

Fu Wei-Neng¹,Liang Ying²,Wei Xin³,Yue Peng-Jie⁴,Zhang Hecheng¹,Li Zhen-Ning⁵,Sun Yuan-Yuan¹

Affiliation:

1. China Medical University

2. China Medical University, The First Affiliated Hospital of China Medical University

3. The First Affiliated Hospital of China Medical University, Shenyang

4. The First Affiliated Hospital of China Medical University

5. Liaoning Province Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University

Abstract

Abstract Abnormality of the chromosomal karyotype is one factor causing poor prognosis in patients with lymphoma. Here, in the analysis of the abnormal karyotype of lymphoma patients, the three smallest overlapregions were found, in which MYCT1 was located. MYCT1 was first cloned by our research team as tumor suppressor gene, but studies related to the occurrence and development of lymphoma have not been reported. In this study, we found MYCT1 could inhibit proliferation and promote cell cycle arrest in diffuse large B-cell lymphoma cells. Moreover, we demonstrate that MYCT1 represses RUNX1 transcription by binding MAX. The findings provide clues and a basis for in-depth studies of MYCT1 in the diagnosis, treatment and prognosis of lymphoma.

Publisher

Research Square Platform LLC

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