Amorphous silica nanoparticle-induced perturbation of cholesterol homeostasis as a function of surface area highlights safe-by-design implementation: an integrated multi-OMICS analysis

Abstract

The systems toxicology approach revealed that the alterations of cholesterol biosynthesis were directly proportional with the surface area of amorphous silica nanoparticles (aSiNPs); the larger the surface area the higher the cholesterol level.