Head-to-tail cyclization for the synthesis of naturally occurring cyclic peptides on organophosphorus small-molecular supports-Reference-Cited by-同舟云学术

Head-to-tail cyclization for the synthesis of naturally occurring cyclic peptides on organophosphorus small-molecular supports

Published:2022 Issue: Volume: Page:
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Li Haidi¹^ORCID,Li Junyou¹,Chao Jie¹^ORCID,Zhang Zixin¹^ORCID,Qin Chuanguang¹^ORCID

Affiliation:

1. MIIT Key Laboratory of Special Functional & Intelligent Polymer materials, MOE Key Laboratory of Supernormal Material Physics & Chemistry, Shaanxi Key Laboratory of Polymer Science & Technology, Department of Chemistry, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China

Abstract

4,4′-bis(diphenylphosphinyloxyl) diphenyl ketoxime and 4-diphenyl phospholoxy benzyl alcohol were designed and prepared as supports for peptide synthesis. The total synthesis of cyclic peptides in a resin-free manner was successfully demonstrated.

Funder

National Natural Science Foundation of China

National College Students Innovation and Entrepreneurship Training Program

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D1QO01362A

Reference43 articles.

1. Cyclic Tetrapeptides from Nature and Design: A Review of Synthetic Methodologies, Structure, and Function

2. Understanding Cell Penetration of Cyclic Peptides